Eating good whole food or taking a nutrient you may not be producing properly seems like a no brainer to me, especially if it will improve your health outcome. The JAMA 2015 study Folate Supplements for Stroke Prevention randomized 20,702 people who had hypertension to an enalapril group or an enalapril with 0.8 mg folate group.
The researchers ended the study early because they found that the group taking enalapril with folate had a significant reduction in strokes – 2.7% taking folate versus 3.4% no folate.
Individuals who have the MTHFR (methylenetetrahydrofolate reductase), defect, the authors speculated, would reap more benefits because they have more difficulty processing folate to methyl-folate. I agree and suspect that people with the MTHFR gene mutation would have even more significant improvements in the folate group had they also been taking a methyl-folate +/- folinic acid supplement.
In the United States, 30-40% of our population has the MTHFR defect. Although many cereals are fortified with folate, providing some people with the MTHFR gene mutation with a higher level of folate, most cereals are also highly processed and loaded with sugar. I also suspect these cereals are supplemented with regular folate not the methyl-folate that those with the MTHFR defect need. So, I wouldn’t recommend eating fortified cereal to increase folate. People with the MTHFR defect would be better off eating whole foods, especially green leafy vegetables and taking a supplement, like DrPaulApproved Methyl-B12 Methyl Folate Intrinsic, or DrPaulApproved MTHFR Brain and Detox.